Pharmaceutical Building Blocks List-01

1      4-(Trifluoromethyl)thiobenzamide [CAS: 72505-21-6]

2 Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate [CAS: 175277-03-9]

3 Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- [CAS: 317318-97-1]

4 2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)thio)phenol [CAS: 636589-63-4]

5 2-(3-Pyrrolidinyl)-1,2,3,4-tetrahydroisoquinolinedihydrochloride [CAS: 1220017-74-2]

6 2-Amino-1-(2-fluorophenyl)ethan-1-one hydrochloride  [CAS: 93102-96-6]

7 2-Amino-2'-fluoroacetophenone [CAS: 736887-62-0]

8 2-amino-1-(2,6-difluorophenyl)ethan-1-one hydrochloride [CAS: 1210255-19-8]

9 2-aMino-1-(2-broMophenyl)ethan-1-one hydrochloride [CAS: 876063-70-6]

10 2-Amino-2'-chloroacetophenone [CAS: 743357-99-5]

11 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride [CAS: 16442-79-8]

12 1-Acetyl-3-broMo-4-chloroindole [CAS: 1375064-70-2]

13 3-Bromo-4-chloroindole [CAS: 1181332-74-0]

14 2,5-DIIODOBENZOIC ACID [CAS: 14192-12-2]

15 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID [CAS: 868851-36-9]

16 Ethyl2-(hydroxyimino)acetoacetate [CAS: 5408-04-8]

17 4,5-difluoro-2-formylbenzonitrile [CAS: 1807177-35-0]

18 2-CHLORO-6-FORMYLBENZONITRILE [CAS: 77532-86-6]

19 4-CHLORO-2-FORMYLBENZONITRILE [CAS: 77532-89-9]

20 2-formyl-4-methoxybenzonitrile [CAS: 21962-52-7]

21 3-methyleneisoindolin-1-one [CAS: 19222-23-2]

22 2-ethyl-3-methyleneisoindolin-1-one [CAS: 320742-26-5]

23 2-benzyl-3-methyleneisoindolin-1-one [CAS: 82359-81-7]

24 5-methoxy-3-methyleneisoindolin-1-one [CAS: 1239331-79-3]

25 5-chloro-3-methyleneisoindolin-1-one [CAS: 1239331-77-1]

26 5,6-difluoro-3-methyleneisoindolin-1-one [CAS: 2389136-66-5]

27 5-bromo-3-chloro-2-(2H-1,2,3-triazol-2-yl)pyridine [CAS: 1335057-78-7]

28 2-(Bromomethyl)-6-fluorobenzonitrile [CAS: 1261686-95-6]

29 3-Pyridazinecarboxylicacid,1,6-dihydro-1-methyl-6-oxo-(6CI) [CAS: 100047-66-3]

30 ethyl 2-(2-formyl-6-methoxyphenoxy)acetate [CAS: 70076-67-4]

31 6-Hydroxypyrimidine-4-carboxylic acid [CAS: 6299-87-2]

32 2-Amino-3-methylbenzamide [CAS: 1885-32-1]

Fullerene C60 (CAS No. 99685-96-8)

Product Introduction:

Fullerene - C60

MF：C60

MW：720.64

CAS：99685-96-8

Purity: 99.5%, 99.9%

Supply Scale: gram scale to kilogram scale

If anyone have interests, please contact with us via angus@sunfinelabs.com

CAS 98327-87-8 | rac-BINAP | Phosphine Ligands For Catalysis

rac-BINAP is a racemic mixture of (R)-BINAP and (S)-BINAP. rac-BINAP is commonly used as a bidentate phosphine ligand in palladium catalyzed cross-coupling reactions.

Structure:

CAS Number: 98327-87-8
Molecular Weight: 622.69 g/mol
Appearance: Off-white to while solid powder
Melting Point: 283-286 C

BINAP is prepared from BINOL via its bistriflate derivatives. Both the (R)- and (S)-enantiomers, as well as the racemate, are commercially available. One of the wide applications include chemoselective hydrogenation, where BINAP is conjugated to rhodium.

For more information, please contact us via angus@sunfinelabs.com

Buchwald Hatwig Amination Reaction and The Phosphine Ligands

The Buchwald–Hartwig amination is a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bondsvia the Palladium-catalyzed coupling reactions of amines with aryl halides. Although Pd-catalyzed C-N couplings were reported as early as 1983, Stephen L. Buchwald and John F. Hartwig have been credited, whose publications between 1994 and the late 2000s established the scope of the transformation. The reaction's synthetic utility stems primarily from the shortcomings of typical methods (nucleophilic substitution, reductive amination, etc.) for the synthesis of aromatic C–N bonds, with most methods suffering from limited substrate scope and functional group tolerance. The development of the Buchwald–Hartwig reaction allowed for the facile synthesis of aryl amines, replacing to an extent harsher methods (the Goldberg reaction, nucleophilic aromatic substitution, etc.) while significantly expanding the repertoire of possible C–N bond formation.

There is a list of phosphine ligands that we are offering for this noble reaction.
XPhos, CAS: 564483-18-7
SPhos, CAS: 657408-07-6
RuPhos, CAS: 787618-22-8
BrettPhos, CAS: 1070663-78-3